qMalaria Lab.

Quantitative Analysis of Malaria

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DSM265 Parameters

  • Number of patients:

  • Pharmacodynamics

  • $${PRR}$$
    $$E_{max}$$

  • $$MIC~~[\frac{ng}{m L}]$$

  • $$\text{Killing window}$$$$(W)$$

  • Parasites features

  • Pharmacokinetics

  • $$\text{Dose}~~[mg]$$

  • $$Cl~~[\frac{L}{kg~h}]$$

  • $$V_c~[\frac{L}{kg}]$$

  • $$V_p~[\frac{L}{kg}]$$

  • $$Q~[\frac{L}{kg~h}]$$

  • $$Tk_0~[h]$$

Efficacy Analysis of DSM265

DSM265 is a novel antimalarial drug featuring satisfactory safety and tolerability. This drug can be combined with artmisinin-based and partner drugs to provide an efficacious treatment for P. falciparum malaria infections.

Learn more about this drug here

Here, you can simulate the model that we have developed to understand how the PK-PD parameters can alter the efficacy of this drug.
In the left sidebar, you can vary the parameters (hover your pointer over them for details), and then click on the below button to simulate the model:

Pharmacokinetics

Pharmacodynamics

Summary Statistics

Parameter values

Download

Initial age distribution