qMalaria Lab.

Quantitative Analysis of Malaria

Parameters

  • Number of patients:

  • Pharmacodynamics

  • PRR


    $$E_{max}$$

  • $$EC_{50}~~[\frac{ng}{m L}]$$


  • $$W$$


  • $$\alpha$$

  • Parasites features

  • Pharmacokinetics

  • Median Weight (kg):

  • $$\text{Doses}~~[mg]$$


    mg/kg body weight

  • $$k_a~~[\frac{1}{h}]$$


  • $$Cl~~[\frac{L}{kg~h}]$$


  • $$V/F~~[\frac{L}{kg}]$$


  • PQ extra parameters

    $$V_c/F~[\frac{L}{kg}]$$

    $$V_p/F~[\frac{L}{kg}]$$

    $$Q/F~[\frac{L}{kg~h}]$$

Triple Artemisnin-based Combination Therapy (TACT)

Artemisin-based combination therapies are losing their efficacy due to an emerging resistance of malaria parasites. TACT is an alternative treatment where an artemisinin derivative, e.g. dihydroartemisinin ( DHA ), is combined with two partner drugs, e.g. piperaquine ( PQ ) and mefloquine ( MQ ), to overcome this threat.

We have devloped a within-host mathematical model that allows us to simulate the pharmacokinetics and pharmacodynamics underpinning the drugs-parasites interactions.

In the left sidebar, you can vary the parameters (hover your pointer over them for details), and then click on the below button to simulate the model:

Pharmacokinetics

Pharmacodynamics

Summary Statistics