Artemisin-based combination therapies are losing their efficacy due to an emerging resistance of malaria parasites. TACT is an alternative treatment where an artemisinin derivative, e.g. dihydroartemisinin ( DHA ), is combined with two partner drugs, e.g. piperaquine ( PQ ) and mefloquine ( MQ ), to overcome this threat.
We have devloped a within-host mathematical model that allows us to simulate the pharmacokinetics and pharmacodynamics underpinning the drugs-parasites interactions.
In the left sidebar, you can vary the parameters (hover your pointer over them for details), and then click on the below button to simulate the model: